Aciphex

Prescription Drug Details: Aciphex

Aciphex contains rabeprazole sodium as an active ingredient in its formulation. Rabeprazole sodium is a substituted benzimidazole proton pump inhibitor (PPI) antiulcer class drug primarily used for the treatment of duodenal ulcers, erosive or ulcerative gastroesophageal reflux disease (GERD), and excessive stomach acid such as Zollinger-Ellison syndrome (ZES).

Aciphex is a medication that is used to treat gastroesophageal reflux disease, or GERD, and other medical conditions where excessive stomach acid is a problem, such as Zollinger-Ellison syndrome. In addition to treating these conditions, Aciphex can also help to heal an esophagus that has become damaged to do high amounts of stomach acid. This medication is also prescribed for the prevention of gastric ulcers.

Aciphex belongs to a group of medications known as proton pump inhibitors. Since the stomach contains proton pumps that are responsible for producing acid, Aciphex decreases the amount of acid that is produced by binding to the proton pumps, which reduces their ability to produce stomach acid.

Indication/Usage: Aciphex is approved for various gastric conditions related to excessive gastric acid secretion. It is primarily used as a short-term therapy for symptomatic relief from duodenal ulcers and erosive or ulcerative gastro-esophageal reflux disease (GERD). Aciphex also helps in GERD-associated symptoms such as in reducing relapse rates of heartburn symptoms and day and night time heartburn. Aciphex is also used as a long-term therapy for pathological hyper-secretion including Zollinger-Ellison syndrome (ZES). In combination with amoxicillin and clarithromycin, Aciphex works to eradicate Helicobacter pylori, thus reducing the risk of duodenal ulcer recurrence. Aciphex is used in various other conditions as follows

• Gastric ulcer (GU),
• Peptic ulcer (PU),
• Healing of duodenal ulcers,
• Healing of erosive esophagitis (damage to esophagus caused by hyper gastric acid secretion).

Dose, Administration and Dosage forms: Aciphex is available in 20mg strength delayed-release enteric-coated light-yellow tablets. Though optimum dosage varies from patient to patient, Aciphex is generally prescribed as 20mg once daily for various indications such as healing and maintenance of erosive or ulcerative GERD, healing of duodenal ulcers (after morning meal), and symptomatic GERD. The tablet should be swallowed wholly and should not be chewed, crushed or split, since doing so will nullify the effects of the enteric coating. Aciphex tablets should be stored at room temperature (15°C to 30°C) in an air tight container away from direct sunlight and moisture.

Mechanism of Action: Aciphex contains the active ingredient rabeprazole sodium, a benzimidazole analogue. Rabeprazole sodium is a proton pump inhibitor (PPI) class drug. Rabeprazole blocks the H+, K+ - ATPase enzyme present on the gastric parietal cell and inhibits gastric acid secretion in the stomach. In gastric parietal cells, rabeprazole gets protonated, accumulated, and transformed into an active sulfonamide thus blocking the final step of gastric acid secretion. This reduced gastric acid secretion allows time for stomach and esophagus ulcers to heal.

Side-effects and safety profile: Rabeprazole sodium is reported to cause numerous side-effects to include: headaches, diarrhea, flatulence, vomiting, nausea, abdominal pains, dry mouth, constipation, meteorism, altered appetite, asthenia, anxiety, sleep problems, increased hepatic enzyme, hepatitis, hepatic encephalopathy, thrombocytopenia, vertigo, pharyngitis, granulocytopenia, dizziness, leukocytopenia, peripheral edema, skin eruption, infection, erythema, myalgia, arthralgia, etc.

Other side-effects reported during post-marketing studies include: hyperammonemia, jaundice, erythema multiforme, disorientation, delirium, anaphylactic reactions, rhabdomyolysis, epidermal necrolysis, interstitial nephritis, bone fractures, hypomagnesemia, etc.

Warnings/Contraindications:

• Aciphex is contraindicated in patients with a known allergy to rabeprazole.
• Aciphex is contraindicated in patients with a known allergy to clarithromycin, amoxicillin and penicillin when used in combination with these drugs.
• Symptomatic response to rabeprazole does not prevent the existence of gastric malignancy.
• Aciphex and warfarin administered concomitantly may cause abnormal bleeding.
• Long-term and multiple daily doses of Aciphex may increase the risk for osteoporosis-related fractures.
• Prolonged treatment with Aciphex is reported to cause hypomagnesemia.
• Aciphex is classified as a pregnancy category B drug, which means it has shown no evidence of causing fetal harm during preclinical research. However, since Aciphex has not yet been studied in pregnant women, it must be used with caution and close monitoring by a healthcare professional.
• Rabeprazole reportedly excretes via breast milk in animals; however, it has not been studied in humans. Therefore, Aciphex should not be used by nursing women.

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