Discount Advair Diskus- Canada Drug Pharmacy

The products listed below either match, relate to, or are possibly therapeutically equivalent to "Advair-diskus". Please note that all prescription products require a VALID PRESCRIPTION written by your doctor to be sent to us to complete your order.

Canada Drugs: Advair Diskus for asthma

Product Listing for Advair Diskus

Advair Diskus Powder is indicated for the treatment of asthma in certain patients. It is also prescribed as a course of therapy for chronic obstructive pulmonary disease (COPD). Physicians may use Advair Diskus for treating other breathing conditions as well.

Advair Diskus is a powder that combines a long-acting corticosteroid and a bronchodilator. This medicine works by widening the air passageway to the lungs and reducing inflammation which in turn helps the patient breathe easier.

Advair Diskus is an inhalation device which delivers the active ingredients fluticasone propionate and salmeterol xinafoate. Present in white powder form, fluticasone has a molecular weight of 500.6. It is almost insoluble in water and somewhat soluble in 95% ethanol. Fluticasone propionate is a corticosteroid which decreases inflammation by inhibiting the body's ability to produce histamines. Salmeterol xinafoate is a bronchodilator and classified as a ?-2 adrenergic agonist. It is usually prescribed for asthma and chronic obstructive pulmonary disease (COPD) patients.


Branded Products

RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide100mcg/50mcg60 dosesBrand$72.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide100mcg/50mcg120 dosesBrand$149.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide100mcg/50mcg180 dosesBrand$197.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide250mcg/50mcg60 dosesBrand$79.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide250mcg/50mcg120 dosesBrand$170.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide250mcg/50mcg180 dosesBrand$222.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide500mcg/50mcg60 dosesBrand$99.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide500mcg/50mcg120 dosesBrand$173.00
RX REQUIREDAdvair Diskus (Fluticasone / Salmeterol) - Known as Seretide500mcg/50mcg180 dosesBrand$237.00
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Generic Drug for Advair Diskus: Fluticasone / Salmeterol

Advair Diskus Indication & Usage

Advair Diskus is prescribed for asthma patients four years old and older. Advair Diskus 250/50 mcg is administered twice daily as a maintenance treatment in chronic obstructive pulmonary disease, as well as chronic bronchitis, emphysema, and exacerbations of COPD.

Advair Diskus is only indicated in cases where long-term asthma control corticosteroids have proven ineffective. The use of Advair Diskus may be discontinued when the prescribing physician determines that a patient's asthma is under control.

It is important to note that Advair Diskus is indicated only for the relief of acute bronchospasm.

Dose, Administration and Dosage forms:

Advair Diskus delivers the drug in powder form by inhalation. It is available in a disposable purple device with 60 blisters in each pack. Each blister contains a combination of fluticasone propionate and salmeterol xinafoate which is orally inhaled in powder form. It is also available in institutional packs which contain 14 blisters per pack.

Mechanism of Action:

Advair Diskus contains two active ingredients, fluticasone propionate and salmeterol xinafoate, which work differently to treat bronchospasm.

Fluticasone propionate:

This tri-fluorinated synthetic corticosteroid works as a strong anti-inflammatory mechanism. Fluticasone propionate has an 18 times greater receptor binding affinity than dexamethasone; roughly double that of beclomethasone; and over 3 times that of budesonide. Since inflammation is an essential component for pathogenesis in asthmatics and COPD patients, corticosteroids are prescribed to inhibit the asthmatic response of multiple cell types, such as mast cells, basophils and macrophages. The anti-inflammatory mechanism of fluticasone propionate inhibits the secretion of histamine and cytokines.

Salmeterol xinafoate: Salmeterol xinafoate is a long acting Beta-2 adrenergic agonist (LABA). Studies indicate that salmeterol xinafoate is around 50 times more selective for Beta-2 receptors than albuterol. Salmeterol xinafoate acts by stimulating intracellular adenyl cyclase enzymes that convert adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cyclic AMP). Increases in cyclic AMP levels result in relaxation of the bronchial smooth muscle and the inhibition of various hypersensitivity mediators from various cells, particularly the mast cells, culminating in appropriate bronchodilation in asthmatics.

Side effects and safety profile:

Clinical trials indicate that one of the active ingredients in the Advair Diskus, salmeterol xinafoate, may be responsible for increasing asthma-related deaths. Other side effects of Advair Diskus may include pneumonia, glaucoma, cataracts, immunosuppression, upper respiratory tract infection, pharyngitis, sinusitis, hoarseness/dysphonia, and bronchitis. It may also cause some non-serious and infrequent side effects like cough, headaches, nausea & vomiting, diarrhea and musculoskeletal pain.

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