Seroquel

About Seroquel

Generic Name: Quetiapine

Seroquel, containing the active ingredient quetiapine fumarate, is classified as a psychotropic medication. Seroquel is prescribed for schizophrenia and related conditions in adults and adolescents 13 years old and older. It can also be indicated for major depression and bipolar disorder. Positive results have been obtained for adult major depressive disorder when Seroquel has been prescribed in combination therapy with antidepressant medicines. Seroquel is a prescription medication which is available in instant release and extended release (Seroquel XR) formulations.

Indication/Usage: Seroquel is usually prescribed for schizophrenia which is a psychotic condition. Seroquel is effective in the treatment of major depressive disorder (MDD) when used in combination with various anti-depressant products. For acute depressive and manic episodes related to bipolar disorder, Seroquel is effective alone or as an add-on therapy with lithium or divalproex. Seroquel is safe for use in adults and children 10 years old and older.

Dose, Administration and Dosage forms: Seroquel is available in varying strength tablet formulations, easily differentiated by color and shape as follows: 25mg (round, peach), 50mg (round, white), 100mg (round, yellow), 200mg (round, white), 300mg (capsule-shaped, white), and 400 mg (capsule-shaped, yellow). The starting dose of Seroquel is 25mg two times per day which can be further titrated based on the results evidenced in individual patients. Seroquel can be administered with or without food. Seroquel tablets should be stored at room temperature (15 to 30°C).

Mechanism of action: Seroquel is an antipsychotic drug and like other antipsychotic drugs, the mechanism of action of Seroquel is of yet unknown. However, the projected mechanism is that it acts as an inhibitor of certain brain receptors. By blocking various neurotransmitters at receptor sites, taking Seroquel results in impaired communication between nerves in the brain. The most common neurotransmitters blocked by Seroquel are dopamine type 2 (D2) and serotonin type 2 (5-HT2) at their respective receptors sites.

Side-effects and safety profile: Side-effects of varying severity have been reported with the use of Seroquel. These side-effects may be associated with the dosage prescribed and the duration of the prescribed treatment. Non-serious side-effects associated with Seroquel are sleepiness, weight gain, irritability, increased appetite, weakness, shortness of breath, dry mouth, runny nose, nasal congestion, indigestion, upset stomach, swelling in hands, feet and ankles, blurred vision, etc. Gastro-intestinal side effects involved with Seroquel are nausea, constipation, and vomiting. Mildly severe side-effects associated with Seroquel are speech issues, rapid heartbeat, hyperglycemia, breast enlargement and abnormal milk secretion from the breast. Serious side-effects associated with Seroquel are lasting and painful erection, excessive bleeding or bruising, suppressed consciousness, seizures, etc. A rare but serious side-effect associated with Seroquel is the impairment of liver function which may result in high cholesterol, and/or impaired thyroid hormone levels.

Warnings and Contraindications: Elderly patients with dementia-associated psychosis should not take Seroquel due to the risk of death.

You should immediately stop taking Seroquel if you develop a high fever, excessive sweating, or a change in heart and pulse rates as these may be symptoms of neuroleptic malignant syndrome (NMS) which is a serious condition that could lead to death.

If you are diabetic or have a family history of diabetes, then you should only take Seroquel after your physician has carefully examined and approved of your glucose levels. Seroquel may further complicate issues involving glucose levels in the blood. These complications could lead to a life threatening situation.

Seroquel increases triglycerides and bad cholesterol levels in the body and decreases good cholesterol, so cholesterol levels should be carefully monitored before and during drug therapy with Seroquel.

You must tell your physician about all prescription and over-the-counter drugs you are taking before taking Seroquel.

If you are pregnant or may become pregnant, you must tell your doctor before starting Seroquel so that you can avoid unwanted results. Seroquel should not be taken while breast-feeding.

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