Tylenol Cold Extra Strength Nighttime helps relieve the symptoms of the common cold. The medication can help relieve certain symptoms of hay fever as well. The combination medication combines acetaminophen, a pain reliever and fever reducer with a cold medication and an extremely mild sedative. A person should take this medication when he suffers from a cold that prevents him from sleeping at night. A person should not use this medication before driving or when he might have to operate heavy machinery.